This page discusses noncovalent bonding's importance in biological systems, highlighting its role in stabilizing DNA and protein structures and enabling key interactions like enzyme-substrate binding ...This page discusses noncovalent bonding's importance in biological systems, highlighting its role in stabilizing DNA and protein structures and enabling key interactions like enzyme-substrate binding and antibody-antigen recognition. The main types of noncovalent forces include ionic interactions (which depend on pH and salt concentration), hydrophobic interactions (favoring nonpolar residues), and hydrogen bonds (involving electronegative atoms and hydrogen).