This page discusses histocompatibility molecules, essential glycoproteins for tissue compatibility in transplants, categorized into Class I and Class II. Class I molecules (HLA-A, HLA-B, HLA-C) presen...This page discusses histocompatibility molecules, essential glycoproteins for tissue compatibility in transplants, categorized into Class I and Class II. Class I molecules (HLA-A, HLA-B, HLA-C) present intracellular antigens to CD8+ T cells, while Class II (HLA-D) presents extracellular antigens to CD4+ T cells. Activation of CD4+ T cells occurs through epitope recognition, leading to proliferation and lymphokine secretion, which recruits immune cells and promotes inflammation.
