This page discusses leukemia, focusing on Chronic Myelogenous Leukemia (CML), which arises from mutated bone marrow stem cells of the myeloid lineage and may lead to a "blast crisis." CML is associate...This page discusses leukemia, focusing on Chronic Myelogenous Leukemia (CML), which arises from mutated bone marrow stem cells of the myeloid lineage and may lead to a "blast crisis." CML is associated with the Philadelphia chromosome due to a translocation of chromosomes 9 and 22. Imatinib mesylate (Gleevec) is a key treatment that can effectively control CML progression and shows promise for other cancers.