The page delves deeply into the regulation of key glycolytic enzymes: hexokinase, phosphofructokinase-1 (PFK-1), and pyruvate kinase. It discusses hexokinase's role in glucose trapping, variability du...The page delves deeply into the regulation of key glycolytic enzymes: hexokinase, phosphofructokinase-1 (PFK-1), and pyruvate kinase. It discusses hexokinase's role in glucose trapping, variability due to isozymes, and the influence of glucose-6-phosphate. The text outlines PFK-1's regulation by allosteric effectors like ATP and AMP, and gluconeogenesis vs. glycolysis control via fructose 2,6-bisphosphate.
The page details the regulatory mechanisms involved in gluconeogenesis, focusing on three key enzymes: pyruvate carboxylase, phosphoenolpyruvate carboxykinase (PEPCK), and fructose-1,6-bisphosphatase....The page details the regulatory mechanisms involved in gluconeogenesis, focusing on three key enzymes: pyruvate carboxylase, phosphoenolpyruvate carboxykinase (PEPCK), and fructose-1,6-bisphosphatase. It discusses how these enzymes are regulated through allosteric effectors and hormonal influences. The page emphasizes the critical roles these enzymes play in controlling gluconeogenesis, thereby maintaining metabolic homeostasis by responding to cellular energy demands.
