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  • https://bio.libretexts.org/Courses/University_of_California_Davis/BIS_2A%3A_Introductory_Biology_-_Molecules_to_Cell/BIS_2A%3A_Introductory_Biology_(Igo)/Ireland_SS2019_Igo/Ireland_SS2019_Igo_Lecture_04/Ireland_2019_Lecture_3/Ireland_2019_Lecture_5
    At whatever level of detail, if we want to create a story describing this process we know that: (a) the description must include an accounting for what happened to the matter in the system (this inclu...At whatever level of detail, if we want to create a story describing this process we know that: (a) the description must include an accounting for what happened to the matter in the system (this includes the change in position of the molecules making up the various parts of the arm and the fuel “burned” to move it) and (b) that some fuel was burned to initiate the movement and therefore, that any description of the process must also include an accounting change in the energy of the system.
  • https://bio.libretexts.org/Courses/University_of_California_Davis/BIS_2A%3A_Introductory_Biology_-_Molecules_to_Cell/BIS_2A%3A_Introductory_Biology_(Igo)/Ireland_SS2019_Igo/Ireland_2019_Lecture_6
    While the overall reaction (the combination of energy cost of breaking bonds, energy gained by making bonds, and the change of entropy between reactants and products) may be negative, the breaking of ...While the overall reaction (the combination of energy cost of breaking bonds, energy gained by making bonds, and the change of entropy between reactants and products) may be negative, the breaking of the bonds requires some energy input which increases the free energy of the system. The pH at which the enzyme is most active will be the pH where the active site R groups are protonated/deprotonated such that the substrate can enter the active site and the initial step in the reaction can begin.

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