This page explains the regulation of tryptophan synthesis in E. coli, which involves five enzymes from a clustered operon. When tryptophan is abundant, it binds to the Trp repressor, a homodimer that ...This page explains the regulation of tryptophan synthesis in E. coli, which involves five enzymes from a clustered operon. When tryptophan is abundant, it binds to the Trp repressor, a homodimer that attaches to the operator of the operon, inhibiting transcription of the genes for enzyme production. This mechanism ensures that enzymes are not synthesized when tryptophan is already present, effectively regulating the metabolic pathway.
