This single pathway is called by different names: the citric acid cycle (for the first intermediate formed—citric acid, or citrate—when acetate joins to the oxaloacetate), the TCA cycle (since citric ...This single pathway is called by different names: the citric acid cycle (for the first intermediate formed—citric acid, or citrate—when acetate joins to the oxaloacetate), the TCA cycle (since citric acid or citrate and isocitrate are tricarboxylic acids), and the Krebs cycle, after Hans Krebs, who first identified the steps in the pathway in the 1930s in pigeon flight muscles.
Under appropriate conditions pyruvate will be oxidized, leading to a loss of one carbon via decarboxylation, and creating acetyl-CoA. The resulting acetyl-CoA can enter any one of several pathways for...Under appropriate conditions pyruvate will be oxidized, leading to a loss of one carbon via decarboxylation, and creating acetyl-CoA. The resulting acetyl-CoA can enter any one of several pathways for the biosynthesis of larger molecules. We will focus on its routing to a central metabolic pathway called the Citric Acid Cycle. Here the remaining two carbons in the acetyl group can either be further oxidized or serve as precursors for the construction of various other molecules.
This single pathway is called by different names: the citric acid cycle (for the first intermediate formed—citric acid, or citrate—when acetate joins to the oxaloacetate), the TCA cycle (since citric ...This single pathway is called by different names: the citric acid cycle (for the first intermediate formed—citric acid, or citrate—when acetate joins to the oxaloacetate), the TCA cycle (since citric acid or citrate and isocitrate are tricarboxylic acids), and the Krebs cycle, after Hans Krebs, who first identified the steps in the pathway in the 1930s in pigeon flight muscles.
