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13.7: The “Poster Boy” of Genetic Research Leading to a Cancer Treatment – Gleevec™ (Imatinib)
https://bio.libretexts.org/Courses/City_College_of_San_Francisco/Introduction_to_Genetics/13%3A_Cancer_Genetics/13.07%3A__The_Poster_Boy_of_Genetic_Research_Leading_to_a_Cancer_Treatment__Gleevec_(Imatinib)
This page discusses chronic myelogenous leukemia (CML), a blood cancer caused by the BCR-ABL chimeric protein leading to unchecked myeloid cell growth. The targeted therapy Gleevec™ (imatinib) inhibit...This page discusses chronic myelogenous leukemia (CML), a blood cancer caused by the BCR-ABL chimeric protein leading to unchecked myeloid cell growth. The targeted therapy Gleevec™ (imatinib) inhibits this protein's kinase activity, effectively managing the disease but not curing it. Treatment challenges arise from patient variability and potential drug resistance, complicating effective management of CML.

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