The chapter on mutation and repair of DNA dealt mainly with small changes in DNA sequence, usually single base pairs, resulting from errors in replication or damage to DNA. The DNA sequence of a chrom...The chapter on mutation and repair of DNA dealt mainly with small changes in DNA sequence, usually single base pairs, resulting from errors in replication or damage to DNA. The DNA sequence of a chromosome can change in large segments as well, by the processes of recombination and transposition. Recombination is the production of new DNA molecule(s) from two parental DNA molecules or different segments of the same DNA molecule; this will be the topic of this chapter.
The page provides an in-depth exploration of homologous recombination, focusing on its significance in DNA repair, genetic diversity during meiosis, and genomic integrity. Key mechanisms are outlined,...The page provides an in-depth exploration of homologous recombination, focusing on its significance in DNA repair, genetic diversity during meiosis, and genomic integrity. Key mechanisms are outlined, including strand invasion, formation of D-loops, and resolution of Holliday junctions. It also discusses the proteins involved and the different pathways like DSBR and SDSA.
