The enzyme primase catalyzes the synthesis of the primers from which DNA polymerases can begin synthesis (Figure 5.21). Primers are short oligonucleotides, ranging from 6 to 60 nucleotides long. They ...The enzyme primase catalyzes the synthesis of the primers from which DNA polymerases can begin synthesis (Figure 5.21). Primers are short oligonucleotides, ranging from 6 to 60 nucleotides long. They can be made of ribonucleotides or a mixture of deoxyribonucleotides and ribonucleotides. The principal primase in E. coli is the 60 kDa protein called DnaG protein, the product of the dnaG gene.