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- https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/12%3A_Cancer/12.07%3A_Chronic_Myelogenous_Leukemia_(CML)This page discusses leukemia, focusing on Chronic Myelogenous Leukemia (CML), which arises from mutated bone marrow stem cells of the myeloid lineage and may lead to a "blast crisis." CML is associate...This page discusses leukemia, focusing on Chronic Myelogenous Leukemia (CML), which arises from mutated bone marrow stem cells of the myeloid lineage and may lead to a "blast crisis." CML is associated with the Philadelphia chromosome due to a translocation of chromosomes 9 and 22. Imatinib mesylate (Gleevec) is a key treatment that can effectively control CML progression and shows promise for other cancers.
- https://bio.libretexts.org/Courses/City_College_of_San_Francisco/Introduction_to_Genetics/13%3A_Cancer_Genetics/13.07%3A__The_Poster_Boy_of_Genetic_Research_Leading_to_a_Cancer_Treatment__Gleevec_(Imatinib)This page discusses chronic myelogenous leukemia (CML), a blood cancer caused by the BCR-ABL chimeric protein leading to unchecked myeloid cell growth. The targeted therapy Gleevec™ (imatinib) inhibit...This page discusses chronic myelogenous leukemia (CML), a blood cancer caused by the BCR-ABL chimeric protein leading to unchecked myeloid cell growth. The targeted therapy Gleevec™ (imatinib) inhibits this protein's kinase activity, effectively managing the disease but not curing it. Treatment challenges arise from patient variability and potential drug resistance, complicating effective management of CML.
- https://bio.libretexts.org/Bookshelves/Introductory_and_General_Biology/Biology_(Kimball)/07%3A_Cell_Division/7.01%3A_ChromosomesThis page discusses the structure of eukaryotic chromosomes, highlighting their composition of DNA and histones, visibility during mitosis as dyads, and features like centromeres and kinetochores. It ...This page discusses the structure of eukaryotic chromosomes, highlighting their composition of DNA and histones, visibility during mitosis as dyads, and features like centromeres and kinetochores. It notes the significance of karyotypes and their role in identifying chromosomal abnormalities like trisomy, which can lead to conditions such as Down syndrome. Additionally, it mentions fluorescence in situ hybridization (FISH) as a technique for locating specific genes within chromosomes.
