This page examines the regulation of DNA replication in eukaryotic cells, emphasizing the control mechanisms during the G2 phase. It describes positive control through the Origin Recognition Complex (...This page examines the regulation of DNA replication in eukaryotic cells, emphasizing the control mechanisms during the G2 phase. It describes positive control through the Origin Recognition Complex (ORC) and licensing factors (Cdc-6 and Cdt-1) essential for replication preparation. Additionally, a negative control system prevents re-replication until post-mitosis. This dual mechanism ensures genomic integrity during cell division.
