This page discusses leukemia, focusing on Chronic Myelogenous Leukemia (CML), which arises from mutated bone marrow stem cells of the myeloid lineage and may lead to a "blast crisis." CML is associate...This page discusses leukemia, focusing on Chronic Myelogenous Leukemia (CML), which arises from mutated bone marrow stem cells of the myeloid lineage and may lead to a "blast crisis." CML is associated with the Philadelphia chromosome due to a translocation of chromosomes 9 and 22. Imatinib mesylate (Gleevec) is a key treatment that can effectively control CML progression and shows promise for other cancers.
This page discusses chronic myelogenous leukemia (CML), a blood cancer caused by the BCR-ABL chimeric protein leading to unchecked myeloid cell growth. The targeted therapy Gleevec™ (imatinib) inhibit...This page discusses chronic myelogenous leukemia (CML), a blood cancer caused by the BCR-ABL chimeric protein leading to unchecked myeloid cell growth. The targeted therapy Gleevec™ (imatinib) inhibits this protein's kinase activity, effectively managing the disease but not curing it. Treatment challenges arise from patient variability and potential drug resistance, complicating effective management of CML.
