This page discusses BCL-2, a proto-oncogene on chromosome 18 involved in cancer by inhibiting apoptosis in B-cells. Its translocation with chromosome 14 (t(14;18)) results in Bcl-2 overexpression, aid...This page discusses BCL-2, a proto-oncogene on chromosome 18 involved in cancer by inhibiting apoptosis in B-cells. Its translocation with chromosome 14 (t(14;18)) results in Bcl-2 overexpression, aiding evasion of programmed cell death, thus promoting cancer. However, this translocation alone does not guarantee cancer, as many carriers remain healthy; other mutations, such as c-myc translocation, also play a role in B-cell malignancies.
