Skip to main content
Biology LibreTexts

Inhibitory Neurotransmitters

The main inhibitory neurotransmitters are GABA (gamma-aminobutyric acid, which is made from Glu through decarboxylation of the a-C group) and glycine. They bind to transmitter-gated chloride channels, which when open hyperpolarize the membrane. Benzodiazepines (like Valium and Librium - anti-anxiety and muscle-relaxing agents) and barbituates (like phenobarbital-hypnotics) bind at allosteric sites and potentiate the binding of each other and GABA. 

Figure: Mechanisms of Channel Gating18gatingchannels.gif