Previous chapters described chromosomes as simple linear DNA molecules on which genes are located. For example, your largest chromosome, chromosome 1, has about 3536 genes. To ensure that each of your cells possesses these genes the chromosome has features that allow it to be passed on during cell division. Origins of replication found along its length provide places for DNA replication to start, telomeres protect each end of the chromosome, and a single centromere near the middle provides a place for microtubules to attach and move the chromosome during mitosis and meiosis.
Figure 9.1: Fluorescence in situ hybridization of mitotic chromosomes from a human cancer cell. (Wikipedia-Pmx-CC:AS)
This chapter examines: (1) changes in the number of whole chromosomes and how they affect the phenotype of an organism and (2) changes in the structure of individual chromosomes and how they affect meiotic pairing. Human examples will be used to show the phenotypic consequences and methods for detection.
Dr. Todd Nickle and Isabelle Barrette-Ng (Mount Royal University) The content on this page is licensed under CC SA 3.0 licensing guidelines.