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Biology LibreTexts

8. Recombination of DNA

The chapter on mutation and repair of DNA dealt mainly with small changes in DNA sequence, usually single base pairs, resulting from errors in replication or damage to DNA. The DNA sequence of a chromosome can change in large segments as well, by the processes of recombination and transposition. Recombination is the production of new DNA molecule(s) from two parental DNA molecules or different segments of the same DNA molecule; this will be the topic of this chapter. Transposition is a highly specialized form of recombination in which a segment of DNA moves from one location to another, either on the same chromosome or a different chromosome; this will be discussed in the next chapter.

Suggested readings

  • Holliday, R. (1964) A mechanism for gene conversion in fungi. Genetics Research 5: 282-304.
  • Orr-Weaver, T. L., Szostak, J. W. and Rothstein, R. J. (1981) Yeast transformation: a model system for the study of recombination. Proc. Natl. Acad. Sci. USA 78: 6354-6358.
  • Szostak, J. W., Orr-Weaver, T. L., Rothstein, R. J. and Stahl, F. W. (1983) The double-strand-break repair model for recombination. Cell 33: 25-35.
  • Stahl, F. W. (1994) The Holliday junction on its thirtieth anniversary. Genetics 138: 241-246.
  • Kowalczykowski, S.C., Dixon, D. A., Eggleston, A. K., Lauder, S. D. and Rehrauer, W. M. (1994) Microbiological Reviews 58:401-465.
  • Eggleston, A. K. and West, S. C. (1996) Exchanging partners: recombination in E. coli. Treand in Genetics 12: 20-25.
  • Edelmann, W. and Kucherlapati, R. (1996) Role of recombination enzymes in mammalian cell survival. Proc. Natl. Acad. Sci. USA 93: 6225-6227.