- Pedigree analysis can be used to determine the mode of inheritance of specific traits such as diseases. Loci can be X- or Y-linked or autosomal in location and alleles either dominant or recessive with respect to wild type.
- If the mode of inheritance is known, a pedigree can be used to calculate the probability of inheritance of a particular genotype by an individual.
- The frequencies of all alleles and genotypes remain unchanged through successive generations of a population in Hardy-Weinberg equilibrium.
- Populations in true Hardy-Weinberg equilibrium have random mating, and no genetic drift, no migration, no mutation, and no selection with respect to the gene of interest.
- The Hardy-Weinberg formula can be used to estimate allele and genotype frequencies given only limited information about a population.
mode of inheritance
mitochondrial inheritance (mtDNA)
p2 + 2pq + q2=1