1.4: The Structure of DNA
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When Watson and Crick set out in the 1940’s to determine the structure of DNA, it was already known that DNA is made up of a series four different types of molecules, called bases or nucleotides: adenine (A), cytosine (C), thymine (T), guanine (G). Watson and Crick also knew of Chargaff’s Rules , which were a set of observations about the relative amount of each nucleotide that was present in almost any extract of DNA. Chargaff had observed that for any given species, the abundance of A was the same as T, and G was the same as C. This was essential to Watson & Crick’s model.