- Find the BLOSUM scores for the conservative substitutions that you sggested in Exercise 1. Does the BLOSUM data support your hypotheses?
- Find the two substitutions with the highest BLOSUM scores. In what ways are the biochemical properties of the substituted amino acid similar or dissimilar to the amino acid that it replaces?
3. Find the three amino acids for which there is no evidence of amino acid substitutions that have occurred more frequently than predicted by chance alone. What special features do these amino acids have?