You may find NCBI’s Amino Acid Explorer helpful for this exercise. You can access Amino Acid Explorer through Google or directly at:
1. Under the amino sequence below, write the same sequence using the 1-letter code. Met-Glu-Asn-Asp-Glu-Leu-Pro-Ile-Cys-Lys-Glu-Asp-Pro-Glu-Cys-Lys-Glu-Asp
2. What is the net charge of this peptide? (Assign -1 for each acidic amino acid and +1 for each basic amino acid. Add up the total charges.)
3. Using the Venn diagram above, propose a conservative substitution for:
Trp - His - Arg - Leu -
4. Write the name of a music group that you enjoy. Then transpose the name into an amino acid sequence written with the 3-letter code. Pass the amino acid sequence to a friend and have him/her decode it. (Note: the 1-letter code uses all of the alphabet, except B, J, O, U, X and Z).