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B14. Links and References

  • Page ID
  • Ion channels for beginners.

    MetaNeuron: a dowloadable program to simulate neural activity (from the U.MN)

    Ion Channels. Org

    Ligand-Gated Ion Channel Database

    Senomyx: Flavors and Taste Receptors

    Animation: Comparison of direct and indirect neurotransmitter actions, ligand-gated vs. G-protein-coupled receptor.


    1. Sobolevsky, A. et al. X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor. Nature 462, 729, 745 (2009)

    2. Xie, Xinan et al. Nicotine binding to brain receptors requires a strong cation-π interaction. Nature doi:10.1038/nature07768 (published March 09)

    3. Sarah C. R. Lummis, Darren L. Beene, Lori W. Lee, Henry A. Lester, R. William Broadhurst, Dennis A. Dougherty. Cis/trans isomerization at a proline opens the pore of a neurotransmitter-gated ion channel. 438, 248 - 252 (2005),

    4. Everts, S. Neuron Activation. C&E News. 44, Oct 2, 2006

    5. Huang, A. et al. The cells and logic for mammalian sour taste detection. Nature 442, pg 934 (2006)

    6. Long, S. B. et al. Crystal Structure of a mammalian voltage-dependent Shaker family K+ Channel. Science 309, 897 (2005); Long, S. B. et al. Voltage Sensor of KV1.2: Structural Basis of Electromechanical Coupling.

    7. Kung, C. A possible unifying principle for mechanosensation. Nature 436, 647 (2005)

    8. Oliver, D. et al. Functional Conversion Between A-Type and Delayed Rectifier K+ Channels by Membrane Lipids. Science. 304, pg 265 (2004)
    9. Davies, A. et al. A Central Role of the BK Potassium Channel in Behavioral Response to Ethanol in C. Elegans. Cell, 115, pg 655 (2003)
    10. Miyazawa, A. et al. Structure and Gating mechanism of the acetylcholine receptor pore. Nature, 423, pg 949 (2003)
    11. Jiang, Y, MacKinnon, R. et al. X-ray structure of a voltage-dependent K+ channel. Nature. 423, pg 33 (2003); The Principle of gating charge movement in a voltage-dependent K+ channel. Nature. 423, pg 42 (2003)
    12. Kandel et al. Principles of Neural Science, 3rd edition. Elsevier (1991). This is the source for much of the material in this section.
    13. Schumacher and Adelman. An Open and Shut Case. (summairzing work on Ca2+-gated K channel from MacKinnon's lab) Nature. 417, pg 501 (2002)
    14. Sun et al. Mechanism of glutamate receptor desenitiziation. Nature. 238. pg 238, 245 (2002)
    15. Dutzler et. al. X-ray structure of a CIC Chloride Channel at 3.0 Angstroms Reveals the molecular basis of anion selectivity. Nature. 415, pg 276, 287 (2002)
    16. Berneche et al. Energetics of Ion Conductions Through the K+ Channel. (use of dynamics) Nature. 414 p 23, 73 (2001)
    17. Sixma et al.. Snails, synapses, and smokers (nicotine/receptor). Nautre, 411, pg 252 (2001)
    18. MacKinnon et al. 50 Years of Inactivation (How K+ channels are closed). Nature. 411, pg 643, 657 (2001)
    19. McGaugh, J. Memory - a century of consolidation. Science. 287. pg 248 (2000)
    20. Wilson et al. Cannabinoids act backward. (drugs that control signaling from cannabinoids) Nature. 410, pg 527, 588 (2001)
    21. McGaugh. Memory - A century of consolidation. Science. pg 248 (2000)
    22. Olney et al. How alcohol damages the brain (Fetal alcohol syndrome). Science. 287, pg 947, 1056 (2000)
    23. Hardy et al. Genetic Classification of Primary Neurodegenerative Disease. Science 282, pg 1075 (1998)
    24. Greenberg et al. Learning more about the NMDA receptor regulation (involved in learning and memory). Science. 295. pg 449, 491 (2002)
    25. Meshorer et el. Alternative Splicing and neuritic mRNA translocation under long-term neuronal hypersensitivity (in PTSD) Science. 295. pg 508 (2002)