Skip to main content
Biology LibreTexts

A9. Antioxidants and Disease

  • Page ID
    5556
  • \( \newcommand{\vecs}[1]{\overset { \scriptstyle \rightharpoonup} {\mathbf{#1}} } \) \( \newcommand{\vecd}[1]{\overset{-\!-\!\rightharpoonup}{\vphantom{a}\smash {#1}}} \)\(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\) \(\newcommand{\id}{\mathrm{id}}\) \( \newcommand{\Span}{\mathrm{span}}\) \( \newcommand{\kernel}{\mathrm{null}\,}\) \( \newcommand{\range}{\mathrm{range}\,}\) \( \newcommand{\RealPart}{\mathrm{Re}}\) \( \newcommand{\ImaginaryPart}{\mathrm{Im}}\) \( \newcommand{\Argument}{\mathrm{Arg}}\) \( \newcommand{\norm}[1]{\| #1 \|}\) \( \newcommand{\inner}[2]{\langle #1, #2 \rangle}\) \( \newcommand{\Span}{\mathrm{span}}\)

    If oxidative damage by dioxygen reduction products can cause disease, maybe antioxidant vitamins (E, C, A), which can form reasonably stable free radical, can protect the body from their effects.

    Figure: antioxidant vitamins (E, C, A)

    antioxidants.gif

    It has been shown that these vitamins can help protect white blood cells from DNA damage arising from hydroxy free radicals. Vitamin E, a fat-soluble vitamin carried in circulating lipoproteins, can reduce the risk of cardiovascular disease, presumably by preventing oxidation of lipids and proteins in lipoproteins. Vitamin E and C, along with a common food additive, butylated hydroxytoluene (BHT) can form stable free radicals (formed possibly by abstraction of a hydrogen atom by hydroxyl free radicals) since the lone electron is stabilized by resonance and the the O-centered resonant form is sterically restricted from intermolecular interactions which could propagate the free radical chain reactions.

    TBA: Recent literature showing link to antioxidants and cancer

    iconexternal_link.gifHuman mitochondrial protein database from the NIST


    This page titled A9. Antioxidants and Disease is shared under a CC BY-NC-SA license and was authored, remixed, and/or curated by Henry Jakubowski.

    • Was this article helpful?