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Biology LibreTexts

G. Predicting Protein Properties From Sequences

  • Page ID
  • Learning Objectives

    • find web based proteomics protein to analyze protein sequences and structures
    • describe the basis for methods used to predict the secondary structure and hydrophobic structures of proteins
    • analyze secondary structure and hydropathy plots from web-based proteomics programs.
    • describe differences between integral and peripheral membranes proteins, and how each could be purified.
    • explain how hydropathy and secondary structure plots can be used to predict membrane spanning sequences of proteins
    • describe in general the theoretical and empirically based methods to predict protein tertiary structure from a primary sequence
    • describe possible early intermediates in protein folding as determined by theoretical methods

    Thumbnail: Structure of human hemoglobin. The proteins α and β subunits are in red and blue, and the iron-containing heme groups in green. From PDB: 1GZX​. (GNU; Proteopedia Hemoglobin).