Skills to Develop
- find web based proteomics protein to analyze protein sequences and structures
- describe the basis for methods used to predict the secondary structure and hydrophobic structures of proteins
- analyze secondary structure and hydropathy plots from web-based proteomics programs.
- describe differences between integral and peripheral membranes proteins, and how each could be purified.
- explain how hydropathy and secondary structure plots can be used to predict membrane spanning sequences of proteins
- describe in general the theoretical and empirically based methods to predict protein tertiary structure from a primary sequence
- describe possible early intermediates in protein folding as determined by theoretical methods
Thumbnail: Structure of human hemoglobin. The proteins α and β subunits are in red and blue, and the iron-containing heme groups in green. From PDB: 1GZX. Image used with permission (GNU; Proteopedia Hemoglobin).